Modafinil pubmed. Publication types Letter .

Modafinil pubmed The following keywords were used alone and in combination to retrieve useful literature on narcolepsy treatment: narcolepsy, Modafinil is a weak inhibitor of dopamine reuptake that leads to an increase in extracellular dopamine. Background: Effects of sodium oxybate (SXB) on patients with narcolepsy with cataplexy (NC) or without cataplexy (NWOC) have not been separately evaluated in clinical trials. Search terms: Pubmed: • modafinil + alzheimer, cognition [meta-analysis], cognition elderly, longevity, aging, neuropathy, cardiovascular, osteoarthritis Clinicaltrials. 5-10 mg/day, n = 22). S. Comparison of pre-post medication changes in pupil diameter showed a decrease after diphenhydramine and an increase after modafinil. For example, MOD-induced improvement of cognitive performance has been explored in several brain disorders in humans that impair cognitive Objectives: To investigate the effect of modafinil 200 mg on the performance of a cohort of healthy male doctors after 1 night of supervised sleep deprivation. Modafinil and Modafinil is a novel wakefulness-promoting agent that has been shown to improve cognitive performance and promote wakefulness among shift workers. One of the first-line treat Following 44 h of continuous wakefulness, participants ingested caffeine 600 mg (N = 12), dextroamphetamine 20 mg (N = 16), modafinil 400 mg (N = 12), or a placebo (N = 14) in a double blind manner, and completed risk-taking measures 2 h later (i. The onset of narcoleptic symptoms usually occurs at an early age and significantly impacts the Introduction. Front Neurol 4, 139. . As well, more safety data are needed on pharmacologic interventions. Chemical Structures of modafinil (MOD) and armodafinil (R-MOD). Further research is needed to determine whether effects of these interventions on multiple sclerosis-related fatigue is influenced by searched PubMed with the search term ‘modafinil’ and reviewed all English-language articles for neurochemical, neurophysiological, cognitive, or information-processing experimental measures. Modafinil promotes wakefulness and is reported to enhance cognition. A total of 12 subjects completed the entire study. ajp. The grey dots represent the individual participants’ scores and the white diamond represents the group mean. 530 No abstract available. Overall, the present results suggest that modafinil has the potential to enhance cognitive conflict processing while leaving emotional conflict processing unaffected. Material/methods: The following electronic databases were searched throughout January 2009: MEDLINE, EMBASE and The Cochrane Library. Modafinil is approved for use in the US and certain European countries for use in patients with excessive sleepiness associated with narcolepsy These results demonstrate that acute oral administration of d-modafinil can lengthen the latency to ejaculation in rats without suppressing sexual behavior. 1176/jnp. Methylphenidate, modafinil and paroxetine were superior to placebo. Objective: To assess the effects of three narcolepsy treatment modalities on sleep stage shifts associated with disrupted nighttime sleep (DNS) using data from a clinical trial. Examples of off-label uses for modafinil include the following: Modafinil has been shown to increase dopaminergic neurotransmission by blocking the dopamine transporter and this may account for its ability to reduce cocaine withdrawal symptoms and reduce the high associated with cocaine use (Volkow et al. This study suggested that modafinil (200 mg) could improve episodic memory and working memory performance in patients with remitted depression. Method: Adult patients with ADHD were randomized in 1:1:1:1:1 fashion to double-blind treatment with modafinil 255, 340, 425, or 510 mg daily or placebo for 9 weeks. Throughout three weeks of abstinence, it decreases subjective afternoon sleepiness. Background: Schizophrenia is associated with widespread cognitive deficits that have an impact on social function. Key themes in this newspaper coverage include the potential 'uses' and 'abuses' of this drug in relation to: (i) Background: To investigate the effects of Modafinil on focused attention, motor function and motor excitability in patients with multiple sclerosis (MS) and fatigue. Like modafinil, the mechanism of action for armodafinil is not fully characterized. PMID: 18178756 DOI: 10. It is the R-enantiomer of the compound modafinil. Modafinil is a wake-promoting compound with low abuse potential used in the treatment of narcolepsy. The clinicians concluded that the modafinil overdose led to severe hyponatraemia and subsequent hyponatraemic cerebral oedema. Modafinil (Provigil is a wake-promoting agent that is pharmacologically distinct from CNS stimulants, such as amfetamine, dexamfetamine and methylphenidate. Resting-state imaging studies have shown that modafinil intake increases regional blood flow in bilateral precentral gyri, left hippocampus, left fusiform gyrus, bilateral lingual gyri, and cerebellum in Treatment-emergent hypomania or mania with modafinil. The novel wake-promoting agent modafinil has been in use for the treatment of several sleep disorders for a few years and is now undergoing clinical trials for its use in the treatment of stimulant addiction, Search in PubMed; View in NLM Catalog; Add to search; Mechanisms of modafinil: A review of current research. 07. Drug Alcohol Depend 106 (2-3), 233–236. g Cognition maintenance is essential for healthy and safe life if sleep deprivation happens. It is used in the treatment of conditions which cause excessive daytime Modafinil, otherwise known as diphenylmethyl‐sulfinyl acetamide, has been proven as an effective agent against daytime fatigue caused by narcolepsy and obstructive sleep apnea (Battleday & Brem, 2016). 2007. In early abstinence, modafinil decreases the objective and subjective sleepiness associated with withdrawal from cocaine. Narcolepsy is a rare neurological disorder that typically necessitates lifelong treatment. However, its daytime side effects, particularly sleepiness, may be troubling for patients and/or may be a necessary part of the patient's treatment journey. Only randomized controlled trials were included. AVL-3288 had a short-term positive effect on memory, but tolerance to these effects developed over time. [PMC free article] [Google Scholar] Background: To assess the effectiveness and safety of modafinil vs. J Head Trauma Rehabil 27: 224-233. , 1999; de Saint Hilaire et al. MATERIAL/METHODS: The following electronic databases were searched throughout January 2009: MEDLINE, EMBASE and The Cochrane Library. ’” Caffeine has anxiolytic effect in acute administration. Neuropharmacology. [PMC free article] [Google ABSTRACT OBJECTIVE: To review the evidence for the use of modafinil in the treatment of attention deficit/hyperactivity disorder (ADHD). Adrafinil, a new molecule identified by a French drug company, L. PMID: 11748325 DOI: 10. 02%–0. The international journal of neuropsychopharmacology 2012, 15:919–929. v68n0624b No abstract available. Further studies are warranted to determine whether the addition of amantadine or modafinil in the weeks after TBI provides benefit. Eligible participants with MS and significant fatigue severity are randomly assigned (1:1:1) to received either CBT, modafinil, or a combination of CBT and modafinil for 12 weeks. gov (www. 2023 Sep;37(9):945-947. This was a randomized, double blind, placebo-controlled 8-week trial of modafinil for cocaine dependence. A spontaneous alternation task was used to evaluate working memory in wild-type mice. Method: 23 participants with a diagnosis of mild-to-moderate probable AD according to National Institute of Neurologic and Communicative Disorder and Stroke Modafinil has atypical DAT binding characteristics and behavioral effects (Schmitt and Reith 2011; Mereu et al. Modafinil is a unique wake-promoting agent for oral administration. Patient accrual was slow, and relatively many patients dropped out during the trial, due mostly to side effects. 001). This pilot trial aims to Modafinil did not exceed the effects of placebo with respect to symptom management. Modafinil (Provigil) is a novel wakefulness-promoting agent that has been shown to have greater efficacy than placebo in the treatment of attention-deficit hyperactivity disorder (ADHD) in children and adults. 1 Background. Authors Stefan P Kruszewski, Steven G Klotz. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Objective: This study evaluated the efficacy and tolerability of modafinil at a range of doses, versus placebo, in alleviating symptoms of ADHD in adults. , 2013). Table 1 presents results of studies in which the effects of modafinil on fatigue and cognition were To summarize the results of all of these studies, the key and consistent findings are: (1) modafinil treatment improves subjective and objective measures of daytime sleepiness; and (2) modafinil treatment does not compromise CPAP use; additional findings include (3) modafinil-treated patients experience a significant improvement in quality of life measures; and (4) modafinil is Despite similar half-lives, plasma concentrations following armodafinil administration are higher late in the day than those following modafinil administration on a milligram-to-milligram basis. Modafinil may potentiate the benefits of cognitive–behavioural therapy (CBT) in chronic fatigue syndrome (CFS). 1097/01. g. Additional references were obtained from reviewed articles. Sleep. Author David T Plante. Method: Patients who were HIV+ and had clinically significant fatigue (according to the Fatigue Severity Scale [FSS]) were included in a 4-week 1 Introduction 1. Modafinil had alerting effects as indicated by reductions in the measures of pupillary fatigue. There is insuffici Randomized controlled studies have also suggested that modafinil may provide benefit as an adjunctive therapy for patients with partial response or non-response to typical antidepressants. Modafinil may improve not only energy but also concentration. 93 Enhanced 5-HT neurotransmission in prelimbic regions may contribute to the increased metabolism in these regions following modafinil because it has been shown to reduce cortical GABA levels through a 5-HT 2 receptor–dependent As compared with placebo, 200 mg of modafinil reduced the maximum level of sleepiness during night-shift work (P<0. 13. 0000255801. 07081279. Disruption of dopamine uptake and signaling has been associated with various psychiatric disorders, The patient also recalled that he had taken methylphenidate. Modafinil (diphenyl-methyl-sulfinyl-2-acetamide, MOD) has been increasingly employed for elevating alertness and vigilance in recent years, yet the underlying There was a significant reduction in CPAP use on modafinil compared to placebo (6. Methylphenidate and modafinil were equivalent to one another. In a pilot study, 5 days of modafinil treatment, compared to placebo, improved working memory and sustained attention functions in 60 cocaine dependent participants who were in early abstinence (Kalechstein et al. Modafinil showed a significant positive effect on fatigue symptoms (95% CI, -0. , 0535). This drug is licensed for narcolepsy and is said to stimulate the respiratory system via the central nervous system. J Pharmacol Exp Ther. 2007 Feb;13(1):52. 32408. Introduction. Objectives: Study objectives were to determine (a) the relative efficacy of three doses of modafinil versus an active control dose of caffeine 600 NDA 20-717 PROVIGIL® (modafinil) Tablets FDA Approved Labeling dated August 17, 2007 PROVIGIL® (modafinil) Tablets [C-IV] Rx Only . Diphenhydramine reduced salivation, and modafinil increased systolic blood pressure. 4. We report their improvement with oral modafinil 200 mg tablets used as a respiratory stimulant, which led to discharge, improved arterial blood gases, and offset further admissions with hypercapnic respiratory failure. The Agency's Committee for Medicinal Products for Human Use (CHMP) has concluded that the benefits of modafinil-containing medicines continue to Rationale: The performance and alertness effects of modafinil were evaluated to determine whether modafinil should replace caffeine for restoring performance and alertness during total sleep deprivation in otherwise healthy adults. Modafinil was well tolerated and did not worsen psychosis. It has been investigated in healthy volunteers, and in individuals with clinical disorders Modafinil is a non-amphetamine central nervous system stimulant with wakefulness-promoting properties. DATA SOURCES: A MEDLINE search (January 1990-May 2006) was conducted using MeSH terms ADHD and modafinil. BACKGROUND: To assess the effectiveness and safety of modafinil vs. Epub 2023 Jul 12. It is used in the treatment of conditions which cause excessive daytime Modafinil is a wake-promoting agent that is pharmacologically different from other stimulants. Despite the likely role of modafinil in improving cognition and arousal in critically ill patients, the available data on the use of modafinil in the ICU setting is limited. 011, PMID: [Google Scholar] 30. Conclusions. The Cochrane Modafinil Prospective Studies Treatment Outcome Substances Benzhydryl Compounds Central Nervous System Stimulants Modafinil Relative to placebo, methylphenidate and modafinil but not 3,4-methylenedioxymethamphetamine improved inhibitory performance. Patients treated with modafinil experienced a significantly prolonged mean sleep latency on the MWT at the end of the study compared with placebo (5. 05% of individuals are affected (Ohayon et al. e. Expert opinion: Loperamide, gabapentin, and modafinil are becoming drugs of abuse, and as such, should be on the radar of healthcare providers. Statistical parametric map of the contrast of drug minus placebo, restricted to the conjunction of the DMN (defined by voxels with TID on both placebo and drug) conjoined with anatomic masks covering the vmPFC, PCC, or bilateral IPL. Conclusions: Modafinil is an effective augmentation strategy for acute depressive episodes, including for symptoms of fatigue, in both unipolar and bipolar disorders. Additionally, the modafinil group experienced reduced daytime sleepiness, while the placebo group showed greater improvement in sleep quality. 6e. 0b013e31824ee1a8. Although its mechanism of action is unknown, modafinil appears to be unlike classic stimulants. Methods: A retrospective, inception cohort design of patients who initiated treatment with modafinil between 2006 and 2008 was used in three US health care claims databases. Paroxetine was superior to modafinil. 24 Like caffeine, modafinil can impair sleep if the sleep period is initiated within modafinil's duration of action. Background and objective: Although there are several treatments for narcolepsy type 2 and idiopathic hypersomnia, studies that assess amphetamines, symptoms beyond sleepiness, and comparative effectiveness are needed. Parkinsonism Relat Disord. The limitations and uncertainties suggest that the authors' conclusions Modafinil does not appear to diffusely increase cortical activation (Ellis et al. Background: Armodafinil is a wake-promoting agent developed by Cephalon that was approved in mid-2007 for the treatment of excessive sleepiness associated with narcolepsy, obstructive sleep apnea and shift work disorder. The search was limited to English-language articles on clinical trials in humans. The evidence base was small, heterogeneous and of unclear quality. We performed a randomized, fully blinded, noninferiority trial of modafinil versus amphetamine-dextroamphetamine in these disorders. Participants were recruited using advertisements and paid $700 in cash for the inpatient stay and an additional $50 in gift 2-[(Diphenylmethyl)sulfinyl]acetamide (modafinil, (±)-1) is a unique dopamine uptake inhibitor that binds the dopamine transporter (DAT) differently than cocaine and may have potential for the treatment of psychostimulant abuse. They found that modafinil increased the cortical pool of all of these substances and attributed modafinil’s neuroprotective effects to its ability to increase creatine The safety and tolerability of modafinil (400 mg/day, n = 14) and mirtazapine (60 mg/day, n = 13) in inpatient methamphetamine withdrawal treatment were compared to a historical comparison group receiving treatment as usual (pericyazine, 2. Rationale: Individuals who experience sleep loss may exhibit certain physiological abnormalities. Keywords: Modafinil promotes wakefulness through an as Modafinil is a non-amphetamine central nervous system stimulant with wakefulness-promoting properties. As early as 1977-78, Michel Jouvet prescribed adrafinil to Purpose: This study examined the potential risk of cardiovascular (CV) events associated with modafinil and the consistency of the risk estimates across databases. The present study may provide a rationale for the treatment of patients with distinct symptoms of impaired attention. Modafinil and mirtazapine were well to Modafinil administration has resulted in cognitive improvement in patients with attention-deficit hyperactivity disorder, major depression, and schizophrenia and in healthy populations (), as well as decreased fatigue in patients with other medical conditions. Methods: Polysomnograms were reviewed from 155 patients (who had these data available at baseline and 8 weeks) of the 278 patients who were randomized to placebo, 9-g sodium oxybate Modafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. 25 Although modafinil's low abuse potential profile makes it more attractive than other controlled stimulants (e. While modafinil produced few effects on sleep measures during the night shift, the largest dose produced several sleep alterations during the day shift. 1. DATA SOUCES: Literature was accessed via MEDLINE (1950-week 3, November 2008), International Pharmaceutical Abstracts, and Google Scholar using Modafinil was developed to promote wakefulness in people with narcolepsy and other sleep disorders, but the stimulant’s reported ability to improve thinking and memory has led to its off-label use as a “smart drug” by people without sleep problems. 8% (20/34) and 27. Treatment is both non-pharmacological and pharmacological, including wake enhancing drugs and stimulants. Modafinil: A closer look at its theoretical toxicological potential J Psychopharmacol. 1097/HTR. Modafinil as a catecholaminergic agent: empirical evidence and unanswered questions. 1177/02698811231187127. Lafon Ltd, in 1974, was found to cause a significant dose-dependent increase in motor activity in mice, without exerting peripheral sympathomimetic effects. Fifteen patients completed the study. We investigated this generality by testing the selectivity of this compound for wake-promoting effects (e. 2001 Fall;13(4):530-1. The protein amounts of A 2A AR, A 2B AR, and exchange protein directly activated by cAMP (Epac) were reduced, while collagen and α-smooth muscle actin (α-SMA) were elevated in DHLFs compared to NHLFs. The d2 alertness test, the Nine Hole Peg Test (9HPT) and Modafinil, a novel compound for treating excessive sleepiness, potently increases wakefulness in laboratory rodents, cats, monkeys and humans. After single or multiple Modafinil in fibromyalgia treatment J Neuropsychiatry Clin Neurosci. Our goal was to compare the efficacy of these three medications with each other and placebo in patients with multiple sclerosis fatigue. Conclusions: Results of this pilot trial do not support routine use of modafinil to treat negative symptoms, cognitive deficits, or wakefulness/fatigue in patients on clozapine. Background: Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in multiple sclerosis; however, the evidence supporting their efficacy is sparse and conflicting. Off-Label Drug Facts is a practitioner-oriented resource for information about specific drug uses that are unapproved by the US Food and Drug Administration. Cognitive deficits identified by cancer survivors consist of a range of difficulties including memory and concentration problems that can emerge during Abstract. The analgesic effect of modafinil and CBT may be mediated by increased activity. Although the compound is reported to affect multiple neurotransmitter systems such as catecholamines, serotonin, glutamate, GABA, orexin, and histamine, however, the molecular mechanism by which moda Modafinil, CBT, and combination therapy were associated with similar reductions in the effects of multiple sclerosis fatigue at 12 weeks. , 2009). Analogs of modafinil, including adrafinil, remain unapproved and/or unscheduled. , 1999); rather, selective brain networks and inter-areal functional connectivity are altered. To further investigate structural requirements for this divergent bindi Supplemental Fig. 2001 Oct; 7 (4):287–288. [] Modafinil with its novel mechanism of action, utilizing multiple neurotransmitter systems such as dopamine, hypocretin, histamine, epinephrine, gamma-aminobutyric acid, and glutamate, is a well-tolerated medication with minimum drug Reichel CM, See RE: Chronic modafinil effects on drug-seeking following methamphetamine self-administration in rats. 2016; Nikiforuk et al. Modafinil is a novel wake-promoting agent approved by the FDA ameliorating excessive daytime sleepiness --their nature, causes, and potential treatments. 26-6. Modafinil also enhances glutamateneurotransmission (Touret et al. Modafinil In Debilitating fatigue After Stroke (MIDAS) will be a phase II, single-centre, prospective, double-blinded, randomised, crossover trial to investigate if modafinil reduces the burden of fatigue after ischaemia in patients who report ongoing severe fatigue (as measured by the Multidimensional Fatigue Inventory (MFI-20)). 01 There was no difference in the cognitive test battery between MOD and placebo, although there was a trend for less false memories in the early recall of the audio material (F(1,15) = There are currently 31 ongoing clinical trials using modafinil, primarily for fatigue due to cancer treatment or substance abuse. This Hospital Pharmacy feature is extracted from Off-Label Drug Facts, a publication available from Wolters Kluwer Health. 41, 42 Differences in the pharmacokinetic profiles, including the absorption and distribution of modafinil, may also be Modafinil is effective for the treatment of several aspects of idiopathic hypersomnia symptomatology, based on studies predominantly including participants with idiopathic hypersomnia without long sleep times, with low risk of bias, and evidence certainty ranging from high to low. The effect of modafinil is more pronounced in the treatment groups compared with the other groups after MCAO. It is a well This review concluded that the evidence supported use of adjunctive modafinil for the safe treatment of depression and fatigue in patients with unipolar or bipolar depression. benztropine and GBR12909 analogs) that have binding properties and behavioral effects that are different from cocaine. Aquí nos gustaría mostrarte una descripción, pero el sitio web que estás mirando no lo permite. clinicaltrials. , relative to locomotor effects) and PubMed, Embase, Medline, PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science and the Cochrane Central Register of Controlled Trials Library, and ClinicalTrials. They have also been used, off-label, as cognitive enhancers in populations of patients with mental disorders, including substance abusers that demonstrate impaired cognitive function. 25 Our study is the first to investigate the benefit of a reference wake-promoting drug, i. While providing effective results in patients with slee Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain. However, rigorous comparative studies with current first-line treatments for ADHD and longer-term independent studies are necessary before modafinil’s role in the treatment of ADHD can be fully established. Discrepancies in ADR labelling for the medications were found across the three countries. 1176/appi Whereas modafinil enhanced cognitive performance in the metacognitive paradigm, confidence indices remained unaffected. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. Modafinil may have potential as a therapeutic agent to help remitted depressed patients with persistent cognitive difficulties. The improvement of memory in chronic period may be associated with the neuroprotective effects of caffeine. The European Medicines Agency has completed a review of the safety and effectiveness of modafinil. 42 to -0. 530. Summary background data: Sleep-deprived and fatigued doctors pose a safety risk to themselves and their patients. 2: Brain regions with augmented task-induced deactivation within the default mode network on modafinil. Design: A 1-year retrospective chart review of all patients receiving modafinil, a wake-promoting agent, to treat opioid-induced sedation. v68n0624b. Objective: To evaluate the effects of modafinil on the intravaginal ejaculatory latency time (IELT) and patient-reported outcomes in patients with lifelong premature ejaculation (PE). , 1997; Ferraro et al. Aims: To study the acute effects of modafinil administration upon brain activity and cognitive performance in people with chronic schizophrenia. In the 4-week study, modafinil significantly improved objectively determined wakefulness and reduced patient-reported sleepiness (MSLT and ESS, respectively) compared with placebo (Pack et al 2001). Opioid-induced sedation was measured using Epworth Sleepiness Scale (ESS Modafinil, which activates cAMP signaling via A 2A AR and A 2B AR, was administered orally. The lack of scheduling has made these analogs a popular Study objective: The purpose of this study was to assess the efficacy of modafinil in combating opioid-induced sedation. The primary outcome is change in fatigue impact as measured by the Modified Fatigue Impact Scale (MFIS) at Objective: To evaluate the efficacy and safety of modafinil in the treatment of fatigue in patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) and to assess effect on depressive symptoms. gov) were repeatedly searched from March 1st to June 1st, 2016 using MeSH terms: “modafinil,” and “attention deficit disorder. 2013, 2017; Cao et al. Global prevalence estimates indicate that approximately 0. 2012. Modafinil is a racemic compound. Modafinil treatment for fatigue associated with fibromyalgia. 2006; 319:561–9. 1994; 17:436–7. Although we found that modafinil may be another treatment option in children and adolescents with ADHD, the results should be interpreted and translated into clinical practice with caution, as the meta-analysis was based on a limited number of clinical trials. Modafinil may need to be prescribed over a prolonged period of months. Modafinil reversed disruptions in cognitive performance and mood during the night shift. Authors Gabriel Background: Fatigue is one of the most disabling symptoms reported by people with multiple sclerosis. Recognizing their unique toxicity profiles is imperative in providing optimal resuscitative care. The Modafinil (2- [ (Diphenylmethyl) sulfinyl] acetamide, Provigil) is an FDA-approved medication with wake-promoting properties. Methods: Retrospective analysis evaluated data from a phase 3, randomized, placebo-controlled trial of SXB, modafinil, and SXB + modafinil versus placebo in adult NC patients (n = 95) or NWOC In this study, TBI patients did not benefit from amantadine or modafinil compared with SOC therapies, and no differences were found between medication groups. The primary efficacy outcome was the change Modafinil: mischaracterization J Clin Psychiatry. DESCRIPTION . ) drug used for the treatment of narcolepsy and sleep disorders. *, p < . PMID: 17592927 DOI: 10. , modafinil, on real driving condition in patients suffering from narcolepsy or IH. At week 4, 51% of patients receiving modafinil had excessive sleepiness that normalized (ie, ESS score <10) compared with 27% of patients Modafinil's therapeutic and chemical class, mechanism of action, pharmacokinetics, indications, dosage, side effects, and drug interactions are also discussed. Efficacy outcomes OSA studies. These findings suggest a positive impact of modafinil on certain neurocognitive functioning and possibly daytime sleepiness, but that it may also have a negative effect on sleep quality. 2008 Jan;165(1):134-5; author reply 135. Publication types Letter Modafinil 100–200 mg/d: 4 unipolar, 3 bipolar: 5 of 7 patients with 50% decrease in depression: None observed: Markovitz et al 43: Open-label case series: 27: Modafinil 200–400 mg/d: Using only PubMed and MEDLINE databases limited the search to Modafinil (brand name Provigil®) is a Schedule IV (U. Although behavioural and pharmacological interventions might be partly beneficial, their combined effects have not been evaluated for multiple sclerosis fatigue, or examined with sufficient consideration of characteristics that might affect treatment response. [Google Scholar] Mignot E, Nishino S, Guilleminault C, Dement WC. 03). , 1994). gov: • modafinil An electronic search of PUBMED, ScienceDirect, and Cochrane Central was conducted for articles published from inception to December 2023 without any language restrictions using the following search string: “(Modafinil OR Provigil OR CRL-40476 OR diphenylmethyl-sulfinyl acetamide) AND (Fatigue OR Tiredness OR MFIS) AND (Multiple These observations are consistent with the ability of modafinil to enhance 5-HT neurotransmission in frontal cortical regions. Modafinil could improve the behavioral deficit and protect the neuron lesion in Parkinson disease models due to its antioxidant activity (Ando et al. Whereas methylphenidate and amphetamine stimulants have a wide distribution of direct neuronal activity throughout the cortex, basal ganglia, and nucleus accumbens, preclinical studies of modafinil demonstrate more limited binding, primarily in the hypothalamus (Lin et al 1996). However, only the tablet formulation is available, which may limit its potential in some circumstances. Central disorders of hypersomnolence include narcolepsy type 1, narcolepsy type 2, idiopathic hypersomnia and hypersomnia associated with medical or mental disorders. Methods: 21 MS patients with fatigue were enrolled in this double-blind placebo-controlled study. Subjective fatigue score per stimulant and their respective placebo condition. Yet, because of the around-the-clock nature of medical practice, doctors frequently care for patients after Modafinil and its R-enantiomer armodafinil are central nervous system stimulants used to improve wakefulness in patients with excessive sleepiness. Mod Pre-Op: modafinil preoperative; Mod Pre + Post Op: modafinil preoperative and postoperative; Non Surg Controls: nonsurgical controls; RAVLT: Rey Auditory Visual Learning Test Discussion A recent review of the literature demonstrates a consensus that exposure to general anesthesia can speed cognitive decline in the elderly population [ 20 - 21 ]. Other, preferably nonpharmacologic intervention studies should be considered to improve symptom managem 2. Both modafinil and armodafinil are associated with a low rate of serum aminotransferase elevations during therapy, but they have not been implicated in cases of clinically apparent acute liver injury. This study suggests that modafinil may improve some aspects of alertness in patients with SAHS who remain sleepy during CPAP therapy, but further studies are required to assess the significance of the reduction in CPAP use. 2017), and is part of an emerging class of drugs (e. During the study period, there was a rapid and statistically significant reduction in the primary outcome, fatigue Objective: To review the efficacy and safety of modafinil in the treatment of cancer-related fatigue (CRF). For methylphenidate, totally 101 ADR categories Modafinil was taken in a fixed dose-titration schedule of 100 mg daily for 7 days followed by 200 mg daily for 7 days. Only Modafinil appears to promote rapid switching of attention in conditions that are most demanding, whilst it offers no benefits in a task that requires unpredictable and infrequent disengagement of attention from an ongoing task in order to act upon an alternative task. Fifty narcoleptics (33 male and 17 female) participated in a multicentric study aimed at assessing the effects of the compound on night sleep, feeling The following scientific databases were used: PubMed, Web of Sciences, and PsycINFO. b Hypothetical model of inverted-U curve Modafinil was administered alone or combined with inhibitors of astrocyte connexin, meclofenamic acid, or flecainide, respectively, acting on Cx30 and Cx43. , 2001) (Arabic gum suspension in saline) produced similar but less potent effects than modafinil dissolved in Methods/design. Modafinil (MOD) or placebo (PL) was administered for 8 weeks. placebo) and the level of sleepiness during Following 47 h of sleep deprivation, the study examined the effect of three stimulant medications (modafinil 400 mg, dextroamphetamine 20 mg, caffeine 600 mg) or placebo on the ability of 54 healthy participants to discriminate and label simple emotional expressions versus complex affect blends (created by morphing photographs of two different affective facial expressions). 5 +/- 1, p = 0. Ondo WG, Dat Vuong K Modafinil for the treatment of excessive daytime sleepiness in Parkinson's disease: a case report. no active treatment or other drugs in the treatment of narcolepsy. neuropharm. We searched PubMed with the search term 'modafinil' and reviewed all English-language articles for neurochemical, neurophysiological, cognitive, or information-processing experimental measures. 05). Central stimulant drugs have been studied in sleep-loss conditions, and some of them might be therapeutically beneficial. The primary function of the dopamine transporter (DAT) is to regulate dopamine levels in the synaptic cleft by transporting the released dopamine back into the presynaptic dopaminergic neurons, thereby terminating dopamine neurotransmission [1,2]. Furthermore, no anhedonia was o Modafinil: A closer look at its theoretical toxicological potential. In particular, three large, drug-company sponsored trials of a film-coated formulation of Do not share your modafinil prescription with anyone, even another person with ADHD. Conclusion: Paroxetine should be further studied in future trials. It was unclear how the results translated into clinical benefit. The greatest delay in ejaculation was observed in animals with shorter baseline ejaculatory Efficacy and Safety of Modafinil for Treatment of Amphetamine-Type Stimulant Use Disorder: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials: Efficacité et innocuité du modafinil pour le traitement des troubles liés à l'usage de stimulants de type amphétamine : revue systématique et méta-analyse d'essais randomisés contrôlés par Study Design. Its pharmacological properties are distinct from those of other CNS agents, and it selectively targets neuronal pathways in the sleep/wake centres of the brain. Objective: This study examined the effects of modafinil on apathetic symptomatology, performance of activities of daily living (ADLs), and caregiver burden in individuals with Alzheimer's disease (AD). 4088/jcp. AEs occurred in 58. Treatment-emergent hypomania or mania with modafinil Am J Psychiatry. Citation 59 In a modafinil dose-comparison study, Black and Hirshkowitz found that modafinil at a dose of 200 mg or 400 mg per day were superior to placebo in improving sleepiness as measured by MWT, ESS, and CGI-C in sleepy CPAP-compliant adults, though there was no significant difference between the two doses. Modafinil binds to the dopamine uptake carrier site with low affinity. Authors J L Schaller, D Behar. Citation Pierard et al (1995) measured the in vivo cortical pool of glutamate-glutamine, aspartate, inositol, and creatine-phosphocreatine using 2D COSY H-NMR. Modafinil enhanced alerting performance and increased activation in the occipital lobe in the alerting network possibly relevant to noradrenergic activity during the ANT task. Patients and methods: Treatment-naïve lifelong PE patients were included in this proof-of-concept study. Modafinil did not reduce negative symptoms or wakefulness/fatigue or improve cognition compared to placebo. , 2002; Partinen and Kronholm, 2017). Armodafinil is a wake-promoting agent against sleep deprivation related disorders. Following cancer treatment, some breast cancer survivors report cognitive impairment, which has commonly been attributed to the receipt of chemotherapy and colloquially termed “chemobrain” (). Sleep-wake states were monitored in wild-type and narcoleptic orexin knockout mice. Existing trials of modafinil for Modafinil has a novel mechanism and is theorized to work in a localized manner, utilizing hypocretin, histamine, epinephrine, gamma-aminobutyric acid, and glutamate. 001 for the change from baseline vs. ” Modafinil does not serve as a reinforcer in cocaine abusers. Affiliation 1 Department of The only previous clinical trial of modafinil for MA dependence examined modafinil 200 mg daily and failed to find an effect for modafinil relative to placebo in pre-planned analyses of retention and MA use, although there was a trend favoring modafinil among highly compliant participants and those without co-morbid opioid dependence (Shearer et al. Here, we report the sy These references are in PubMed. Excessive daytime sleepiness (EDS), of very similar pattern to that seen in narcolepsy syndrome, is extremely common in myotonic dystrophy type 1 (DM1). 1016/j. [Google Scholar] Montastruc JL, Rascol O. The different pharmacokinetic profile of armodafinil may result in Some healthcare professionals choose to prescribe modafinil for other conditions that the FDA does not explicitly approve, which is called off-label prescribing. Scoriels L, Neuroprotective effects of modafinil. doi: 10. Indeed, it has shown promise as a therapy for cognitive disfunction resulting These data suggest that the response to 200 mg/day modafinil is greater in Japanese patients than in US patients, which may indicate slight differences in pharmacokinetic profiles among different ethnicities, as already reported among other ethnic groups. This new guide to t Sleep restriction therapy (SRT) is an effective stand-alone behavioural intervention for insomnia disorder. a Cellular model of modafinil action on LC-NE neuron, indicating how NET inhibition (red Xs on schematic neuron in second row) by modafinil increases NE at the cell-body α 2 autoreceptor, leading to moderately-slowed tonic discharge rate, and increased NE release (via both enhanced task-related discharge and terminal NET inhibition). You should not take modafinil if you have any of the following conditions: allergy or hypersensitivity to modafinil, armodafinil or any of the ingredients in modafinil medications. Modafinil also improves the ability to stay awake under sleep-conducive conditions (sleep loss and adverse circadian phase) in a dose-dependent fashion. (2013) 64:168–84. Authors Thomas L Schwartz 1 , Sheetal Rayancha, Ayesha Rashid, Susan Chlebowksi, Mark Chilton, Martin Morell. In this review we summarize and discuss previously published research on modafinil’s neural, cytoprotective, and cognitive effects, and we propose possible primary biochemical targets Modafinil is a novel wake-promoting agent approved by the FDA ameliorating excessive daytime sleepiness (EDS) in three disorders: narcolepsy, shift work sleep disorder and obstructive sleep apnea. Objective and subjective measures of sleep were also disrupted, but to a lesser extent. Pre-clinical studies of modafinil suggest a Modafinil did not cause a clinically significant increase of heart rate, systolic blood pressure, and diastolic blood pressure. Rationale and objectives: Modafinil (MOD) and its R-enantiomer (R-MOD) are approved medications for narcolepsy and other sleep disorders. Sir, Treatment of bipolar depression in the elderly is challenging due to the presence of medical comorbidities and it is often resistant to treatment. Modafinil seems to fit the This article reviews the use of modafinil in palliative care, and its use in Modafinil was also not different than placebo in improving cognitive performance during the study participation. Modafinil is primarily prescribed for the treatment of several kinds of sleep disorders. [PMC free article] [Google Scholar] Wisor J, 2013. Modafinil did not improve planning or sustained attention. Self-estimated IELTs of the patients were recorded and the Premature Ejaculation Profile (PEP Indications restricted following review procedure under Article 31 of Directive 2001/83/EC as amended. This article reviews the studies on modafinil administration and cognitive performance as they relate to military operations and the provision of health care by sleep-deprived individuals. Modafinil treatment for fatigue associated with fibromyalgia J Clin Rheumatol. 1176/appi. Publication types Letter Objective: Psychostimulants are the first-line treatment in adults with attention-deficit hyperactivity disorder (ADHD). A 13 th participant completed one part of the study (modafinil portion), and his data were included in the final analyses, so outcomes are presented as N=12 or N=13. Sharing prescription medication is illegal, and can cause harm. 17–18 A review by Chang, Sato, and Han 19 found that modafinil may be an affective adjunctive treatment for depression, but is most appropriate for targeting somatic symptoms of This review concluded that the evidence supported use of adjunctive modafinil for the safe treatment of depression and fatigue in patients with unipolar or bipolar depression. The aim of the study was to review the novel usage of modafinil for alleviation of fatigue, excessive daytime somnolence (EDS), and/or depression in critically ill patients. In fact, one study from 2013 found that nearly 90% of individuals taking modafinil were prescribed the drug off-label. It is also known to be used recreationally. Methylphenidate significantly increased activation in the right middle frontal gyrus, middle/superior temporal gyrus, inferior parietal lobule, presupplementary motor area, and anterior cingulate cortex compared with The present results suggest that modafinil, given early in the morning, has positive effects on sleep and sleepiness in chronic cocaine users. This meta-analysis aimed to evaluate the efficacy, acceptability, and tolerability of lisdexamfetamine (LDX), mixed amphetamine salts (MASs), modafinil (MDF), and methylphenidate (MPH) in comparison with placebo. This paper examines the social construction of the new wakefulness-promoting drug Modafinil (brand name Provigil) in the British press. 0% (10/37) of patients in the modafinil and placebo groups, respectively. The study was conducted at the University of Pennsylvania Treatment Research Center’s outpatient facility, and its objective was to evaluate the efficacy of modafinil treatment for cocaine dependence based on quantitative BE levels and self-reported use. Recently, the therapeutic efficacies of modafinil in the improvement of cognition in Parkinson's Modafinil has been shown to significantly improve cognitive performance including executive functions in healthy subjects in normal and sleep deprived conditions. A total of 75 ADR categories were listed for atomoxetine and 80% of these were listed in all three countries. , 1996; Ferraro et al. An electronic search of PUBMED, ScienceDirect, and Cochrane Central was conducted for articles published from inception to December 2023 without any language restrictions using the following search string: “(Modafinil OR Provigil OR CRL‐40476 OR diphenylmethyl‐sulfinyl acetamide) AND (Fatigue OR Tiredness OR MFIS) AND (Multiple Sclerosis OR MS). PROVIGIL (modafinil) is a wakefulness-promoting agent for oral administration. , 1994; Ferraro et al. In fact, because of the low solubility of modafinil, we tested different vehicles and found that modafinil administered in the vehicle used in several previous studies (Tanganelli et al. 3 +/- 1 h/ night; 6. This may not be the complete list of references from this article. 1 Subjects. 77 min; p < 0. In a significant minority it has a profound disabling effect on employment, social functioning Chemical structures of modafinil, methylphenidate, amphetamine, and pemoline. 02 min, 95% confidence interval: 3. The cognitive enhancing effects of MOD and their neural correlates are being extensively investigated preclinically and in humans (Minzenberg and Carter 2008). rhu. , 2018). This was at a much lower dose than the modafinil (he estimates less than 200 mg, while the modafinil was more than 600 mg). The adverse events were no different from placebo. Combination therapy was not associated with augmented improvement compared with the individual interventions. Treatment Modafinil is a central putative alpha-1 postsynaptic agonist with vigilance-promoting properties. We additionally summarized the pharmacokinetic profile of modafinil and clinical efficacy in psychiatric patients. Modafinil (MOD) is a wakefulness-inducing compound prescribed for treatment of excessive daytime sleepiness as a consequence of sleep disturbances such as shift work sleep disorder, obstructive sleep apnea, restless leg syndrome, or narcolepsy. Modafinil (diphenylmethyl‐sulfinyl‐2 acetamide) is a nonamphetaminergic psychoactive drug with multiple positive effects on wakefulness, locomotor activity, and cognitive ability. 2007 Jun;68(6):970-1; author reply 971-2. Modafinil could potentially be a valuable new treatment option for patients with ADHD. jkuggfzx uhgz nug jhc sll wwjjgcu nqdabl mqnh asc roiclb